A review of machine learning-based methods for predicting drug-target interactions.

The prediction of drug-target interactions (DTI) is a crucial preliminary stage in drug discovery and development, given the substantial risk of failure and the prolonged validation period associated with in vitro and in vivo experiments. In the contemporary landscape, various machine learning-based methods have emerged as indispensable tools for DTI prediction. This paper begins by placing emphasis on the data representation employed by these methods, delineating five representations for drugs and four for proteins. The methods are then categorized into traditional machine learning-based approaches and deep learning-based ones, with a discussion of representative approaches in each category and the introduction of a novel taxonomy for deep neural network models in DTI prediction. Additionally, we present a synthesis of commonly used datasets and evaluation metrics to facilitate practical implementation. In conclusion, we address current challenges and outline potential future directions in this research field.

Digital Filtering Techniques Using Fuzzy-Rules Based Logic Control.

This paper discusses current formulations based on fuzzy-logic control concepts as applied to the removal of impulsive noise from digital images. We also discuss the various principles related to fuzzy-ruled based logic control techniques, aiming at preserving edges and digital image details efficiently. Detailed descriptions of a number of formulations for recently developed fuzzy-rule logic controlled filters are provided, highlighting the merit of each filter. Fuzzy-rule based filtering algorithms may be designed assuming the tailoring of specific functional sub-modules: (a) logical controlled variable selection, (b) the consideration of different methods for the generation of fuzzy rules and membership functions, (c) the integration of the logical rules for detecting and filtering impulse noise from digital images. More specifically, we discuss impulse noise models and window-based filtering using fuzzy inference based on vector directional filters as associated with the filtering of RGB color images and then explain how fuzzy vector fields can be generated using standard operations on fuzzy sets taking into consideration fixed or random valued impulse noise and fuzzy vector partitioning. We also discuss how fuzzy cellular automata may be used for noise removal by adopting a Moore neighbourhood architecture. We also explain the potential merits of adopting a fuzzy rule based deep learning ensemble classifier which is composed of a convolutional neural network (CNN), a recurrent neural networks (RNN), a long short term memory neural network (LSTM) and a gated recurrent unit (GRU) approaches, all within a fuzzy min-max (FMM) ensemble. Fuzzy non-local mean filter approaches are also considered. A comparison of various performance metrics for conventional and fuzzy logic based filters as well as deep learning filters is provided. The algorhitms discussed have the following advantageous properties: high quality of edge preservation, high quality of spatial noise suppression capability especially for complex images, sound properties of noise removal (in cases when both mixed additive and impulse noise are present), and very fast computational implementation.

Focal Boundary Dice: Improved Breast Tumor Segmentation from MRI Scan.

Focal Boundary Dice, a new segmentation evaluation measure, was hereby presented, with the focus on boundary quality and class imbalance. Extensive analysis was carried out across different error types with varied object sizes of imaged tumors from Magnetic Resonance Imaging (MRI) scans, and the results show that Focal Boundary Dice is significantly more adaptive than the standard Focal and Dice measures to boundary errors for imaged tumors from MRI scans and does not over-penalize errors on the division of the boundary, including smaller imaged objects. Based on Boundary Dice, the standard evaluation protocols for tumor segmentation tasks were updated by proposing the Focal Boundary Dice. The contradiction between the target and the background area, and the conflict between the importance and the attention of boundary features were mainly solved. Meanwhile, a boundary attention module was introduced to further extract the tumor edge features. The new quality measure presents several desirable characteristics, including higher accuracy in the selection of hard samples, prediction/ground-truth pairs, and balanced responsiveness with across scales, which jointly make it more suitable for segmentation evaluation than other classification-focused measures such as combined Intersection-over-Union and Boundary binary cross-entropy loss, Boundary binary cross-entropy loss and Shape-aware Loss. The experiments show that the new evaluation metrics allow boundary quality improvements and image segmentation accuracy that are generally overlooked by current Dice-based evaluation metrics and deep learning models. It is expected that the adoption of the new boundary-adaptive evaluation metrics will facilitate the rapid progress in segmentation methods, and further contribute to the improvement of classification accuracy.

MRI Radiogenomics in Precision Oncology: New Diagnosis and Treatment Method.

Precision medicine for cancer affords a new way for the most accurate and effective treatment to each individual cancer. Given the high time-evolving intertumor and intratumor heterogeneity features of personal medicine, there are still several obstacles hindering its diagnosis and treatment in clinical practice regardless of extensive exploration on it over the past years. This paper is to investigate radiogenomics methods in the literature for precision medicine for cancer focusing on the heterogeneity analysis of tumors. Based on integrative analysis of multimodal (parametric) imaging and molecular data in bulk tumors, a comprehensive analysis and discussion involving the characterization of tumor heterogeneity in imaging and molecular expression are conducted. These investigations are intended to (i) fully excavate the multidimensional spatial, temporal, and semantic related information regarding high-dimensional breast magnetic resonance imaging data, with integration of the highly specific structured data of genomics and combination of the diagnosis and cognitive process of doctors, and (ii) establish a radiogenomics data representation model based on multidimensional consistency analysis with multilevel spatial-temporal correlations.

U-Net-Based Medical Image Segmentation.

Deep learning has been extensively applied to segmentation in medical imaging. U-Net proposed in 2015 shows the advantages of accurate segmentation of small targets and its scalable network architecture. With the increasing requirements for the performance of segmentation in medical imaging in recent years, U-Net has been cited academically more than 2500 times. Many scholars have been constantly developing the U-Net architecture. This paper summarizes the medical image segmentation technologies based on the U-Net structure variants concerning their structure, innovation, efficiency, etc.; reviews and categorizes the related methodology; and introduces the loss functions, evaluation parameters, and modules commonly applied to segmentation in medical imaging, which will provide a good reference for the future research.

A Review on the Rule-Based Filtering Structure with Applications on Computational Biomedical Images.

In this paper, we present rule-based fuzzy inference systems that consist of a series of mathematical representations based on fuzzy concepts in the filtering structure. It is crucial for understanding and discussing different principles associated with fuzzy filter design procedures. A number of typical fuzzy multichannel filtering approaches are provided in order to clarify the different fuzzy filter designs and compare different algorithms. In particular, in most practical applications (i.e., biomedical image analysis), the emphasis is placed primarily on fuzzy filtering algorithms, with the main advantages of restoration of corrupted medical images and the interpretation capability, along with the capability of edge preservation and relevant image information for accurate diagnosis of diseases.

MRI radiogenomics for intelligent diagnosis of breast tumors and accurate prediction of neoadjuvant chemotherapy responses-a review.

BACKGROUND AND OBJECTIVE: This paper aims to overview multidimensional mining algorithms in relation to Magnetic Resonance Imaging (MRI) radiogenomics for computer aided detection and diagnosis of breast tumours. The work also aims to address a new problem in radiogenomics mining: how to combine structural radiomics information with non-structural genomics information for improving the accuracy and efficacy of Neoadjuvant Chemotherapy (NAC). METHODS: This requires the automated extraction of parameters from non-structural breast radiomics data, and finding feature vectors with diagnostic value, which then are combined with genomics data. In order to address the problem of weakly labelled tumour images, a Generative Adiversarial Networks (GAN) based deep learning strategy is proposed for the classification of tumour types; this has significant potential for providing accurate real-time identification of tumorous regions from MRI scans. In order to efficiently integrate in a deep learning framework different features from radiogenomics datasets at multiple spatio-temporal resolutions, pyramid structured and multi-scale densely connected U-Nets are proposed. A bidirectional gated recurrent unit (BiGRU) combined with an attention based deep learning approach is also proposed. RESULTS: The aim is to accurately predict NAC responses by combining imaging and genomic datasets. The approaches discussed incorporate some of the latest developments in of current signal processing and artificial intelligence and have significant potential in advancing and provide a development platform for future cutting-edge biomedical radiogenomics analysis. CONCLUSIONS: The association of genotypic and phenotypic features is at the core of the emergent field of Precision Medicine. It makes use of advances in biomedical big data analysis, which enables the correlation between disease-associated phenotypic characteristics, genetics polymorphism and gene activation to be revealed.

Automatic breast tissue segmentation in MRIs with morphology snake and deep denoiser training via extended Stein's unbiased risk estimator.

Accurate segmentation of the breast tissue is a significant challenge in the analysis of breast MR images, especially analysis of breast images with low contrast. Most of the existing methods for breast segmentation are semi-automatic and limited in their ability to achieve accurate results. This is because of difficulties in removing landmarks from noisy magnetic resonance images (MRI). Especially, when tumour is imaged for scanning, how to isolate the tumour region from chest will directly affect the accuracy for tumour to be detected. Due to low intensity levels and the close connection between breast and chest portion in MRIs, this study proposes an innovative, fully automatic and fast segmentation approach which combines histogram with inverse Gaussian gradient for morphology snakes, along with extended Stein's unbiased risk estimator (eSURE) applied for unsupervised learning of deep neural network Gaussian denoisers, aimed at accurate identification of landmarks such as chest and breast.

Artificial Intelligence in Breast MRI Radiogenomics: Towards Accurate Prediction of Neoadjuvant Chemotherapy Responses.

Neoadjuvant Chemotherapy (NAC) in breast cancer patients has considerable prognostic and treatment potential and can be tailored to individual patients as part of precision medicine protocols. This work reviews recent advances in artificial intelligence so as to enable the use of radiogenomics for accurate NAC analysis and prediction. The work addresses a new problem in radiogenomics mining: How to combine structural radiomics information and non-structural genomics information for accurate NAC prediction. This requires the automated extraction of parameters from structural breast radiomics data, and finding non-structural feature vectors with diagnostic value, which then are combined with genomics data acquired from exocrine bodies in blood samples from a cohort of cancer patients to enable accurate NAC prediction. A self-attention-based deep learning approach, along with an effective multi-channel tumour image reconstruction algorithm of high dimensionality, is proposed. The aim was to generate non-structural feature vectors for accurate prediction of the NAC responses by combining imaging datasets with exocrine body related genomics analysis.

Artery/vein classification of retinal vessels using classifiers fusion.

The morphological changes in retinal blood vessels indicate cardiovascular diseases and consequently those diseases lead to ocular complications such as Hypertensive Retinopathy. One of the significant clinical findings related to this ocular abnormality is alteration of width of vessel. The classification of retinal vessels into arteries and veins in eye fundus images is a relevant task for the automatic assessment of vascular changes. This paper presents an important approach to solve this problem by means of feature ranking strategies and multiple classifiers decision-combination scheme that is specifically adapted for artery/vein classification. For this, three databases are used with a local dataset of 44 images and two publically available databases, INSPIRE-AVR containing 40 images and VICAVR containing 58 images. The local database also contains images with pathologically diseased structures. The performance of the proposed system is assessed by comparing the experimental results with the gold standard estimations as well as with the results of previous methodologies, achieving promising classification performance, with an over all accuracy of 90.45%, 93.90% and 87.82%, in retinal blood vessel separation for Local, INSPIRE-AVR and VICAVR dataset, respectively.

Pattern identification of biomedical images with time series: Contrasting THz pulse imaging with DCE-MRIs.

OBJECTIVE: We provide a survey of recent advances in biomedical image analysis and classification from emergent imaging modalities such as terahertz (THz) pulse imaging (TPI) and dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) and identification of their underlining commonalities. METHODS: Both time and frequency domain signal pre-processing techniques are considered: noise removal, spectral analysis, principal component analysis (PCA) and wavelet transforms. Feature extraction and classification methods based on feature vectors using the above processing techniques are reviewed. A tensorial signal processing de-noising framework suitable for spatiotemporal association between features in MRI is also discussed. VALIDATION: Examples where the proposed methodologies have been successful in classifying TPIs and DCE-MRIs are discussed. RESULTS: Identifying commonalities in the structure of such heterogeneous datasets potentially leads to a unified multi-channel signal processing framework for biomedical image analysis. CONCLUSION: The proposed complex valued classification methodology enables fusion of entire datasets from a sequence of spatial images taken at different time stamps; this is of interest from the viewpoint of inferring disease proliferation. The approach is also of interest for other emergent multi-channel biomedical imaging modalities and of relevance across the biomedical signal processing community.